Immune responses against Aspergillus fumigatus
نویسندگان
چکیده
منابع مشابه
Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis.
OBJECTIVES The objectives of this study were to determine the prevalence of Aspergillus fumigatus and Candida albicans in the sputa of patients with cystic fibrosis (CF), to assess serologic IgE responses of these patients to the presence of fungi in the sputum, to evaluate what effect this may have on clinical status, and to determine how the above-mentioned factors relate to allergic bronchop...
متن کاملThe innate immune response to Aspergillus fumigatus.
Despite the development of new treatments, the mortality due to invasive pulmonary aspergillosis remains above 50%, reaching 95% in certain situations. The battle against Aspergillus fumigatus involves several components of the pulmonary innate immune system: cells, mediators, and natural antifungal molecules involved in the recognition and elimination of the fungus, thereby preventing coloniza...
متن کاملTLR9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice
The role of toll like receptor-9 (TLR9) in anti-fungal responses in the immunodeficient and allergic host is presently unclear. Herein, we investigated the role of TLR9 in murine models of invasive aspergillosis and fungal asthma. Neutrophildepleted TLR9 wildtype (TLR9) and TLR9 deficient (TLR9) mice were challenged with resting or swollen A. fumigatus conidia and monitored for survival and lun...
متن کاملHypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells.
Aspergillus fumigatus is an opportunistic mould that causes invasive pulmonary aspergillosis (IPA), a life-threatening infection in immunocompromised patients. During the course of IPA, localised areas of tissue hypoxia occur. Bacterial infection models revealed that hypoxic microenvironments modulate the function of host immune cells. However, the influence of hypoxia on anti-fungal immunity h...
متن کاملDistinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae.
Aspergillus fumigatus is the most common filamentous fungal pathogen of immunocompromised hosts, resulting in invasive aspergillosis (IA) and high mortality rates. Innate immunity is known to be the predominant host defense against A. fumigatus; however, innate phagocyte responses to A. fumigatus in an intact host and their contributions to host survival remain unclear. Here, we describe a larv...
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ژورنال
عنوان ژورنال: Current Opinion in Infectious Diseases
سال: 2011
ISSN: 0951-7375
DOI: 10.1097/qco.0b013e328348b159